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Intes, Xavier; Ochoa, Marien; Yaseen, Mohammad A (Ed.)Not AvaIn this study, a novel near-infrared (NIR) ICG-based J-aggregate contrast agent was used for photoacoustic tomography (PAT) to image whole organs in a nude mouse model. NIR-PAT obtained at the 895-nm absorption peak of our nanoparticles, we were able to resolve organs of interest that included the liver and kidney along with vasculature deeper into biological tissue while maintaining fine spatial resolution. NIR-PAT shows promising applications in small-animal functional imaging, including measuring oxygen saturation levels and studying biodistribution of contrast agents, leading to potential clinical imaging studies for drug development and delivery, and angiographic studies.ilablemore » « lessFree, publicly-accessible full text available March 21, 2026
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